Our research is focused on the application of biologically active polysaccharide materials and adult stem cells to problems in tissue engineering and regenerative medicine. We aim to apply engineering principles to the study and manipulation of living cells with the ultimate goal of producing tissue regeneration, repair, or in vitro tissue models. The design, synthesis and evaluation of biologically active materials are integral parts of this effort. Among natural polymers, the ionic polysaccharides known as glycosaminoglycans (GAGs) are of particular interest in our work. We are currently examining their use as components of tissue scaffolds for a number of tissue repair and regeneration projects.